Pengaruh Cangkang Keong Sawah (Pila ampullacea) Terhadap Pembentukan Tulang Baru (Remodeling Tulang)

Background: Rice fields conch is believed by people as an alternative medicine that capable to treat many kind
of diseases, such as diabetes, jaundice, liver, ulcer, cholesterol, and preventing osteoporosis, more in-depth
scientific studies regarding the efficacy of rice field conch for human health are still not widely done. All of this
statement are still empirical data from the experiences of rice field conch users, so it needs further research.
Objective: To determine whether the content of the rice field conch shell (Pila ampullacea) can affect the bone
remodeling process. Method: Types of research that has been used was laboratory experiment with control
group post test only design. The population of this research used white type of rat Galur Wistar (Rattus
norvegicus L.), with the minimum number of samples needed are 4 rats from each group. So total of the samples
are 20 white rats Galur Wistar (Rattus norvegicus L.). Research conducted at the Pharmacology Laboratory of
Andalas University, Anatomical pathology Laboratory Siti rahmah islamic hospital and Anatomical Pathology
Laboratory Andalas University using Oneway ANOVA test. Result: The results of the research obtained that the average number of osteoblasts in the control group (-) with the lowest average number of osteoblasts was 14.3
per five fields of view. The highest increase in average occurred in the administration of Pila ampullacea 100
mg, which is 36.6 per five fields of view. The average number of osteoclasts in the control group (-) was also
seen to be the lowest at 1.55 per five fields of view and the increase of osteoclasts average was highest in the
administration of 100 mg of ampullacea, which was 3.25 per five fields of view and it was shown that the supply
of rice field conch shell powder (Pila ampullacea) could affect bone remodeling processes with p <0.05.
Conclusion: There is an effect of giving ground snail shell powder (Pila ampullacea) in the process of forming
osteoblasts and osteoclasts. There is a significant effect at the dose of 100 mg.